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In the SURMOUNT-2 trial for adults with type 2 diabetes, tirzepatide 15 mg produced 14.7% mean weight loss at 72 weeks

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Digestion Samples were dried and dissolved in 8M urea, 50mM triethylammonium bicarbonate (TEAB), 10 mM dithiothreitol (DTT) and disulfide bonds were reduced for 1 hour at room temperature