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Metformin induces cell cycle arrest and apoptosis in drug-resistant leukemia cells

In select cases, oral formulations exist but may be used for other indications

The largest age group is 65+

Mechanistic studies suggest that the potential direct cardiovascular benefits of SGLT2i include augmentation of signal transducer and activator of transcription 3 (STAT3), inhibition of sodium hydrogen exchange (sodium-hydrogen antiporter 1 [NHE-1]), improved mitochondrial metabolism, modulation of natriuretic peptides, improved vascular stiffness and autonomic tone, reduction of inflammation, and improved cardiac energetics

The WBC population was separated by hypotonic lysis of erythrocytes with red blood cell lysate (Solarbio, Beijing, China)