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These routes converge with PI3K/Akt and AMPK to activate eNOS and dampen NF-B, thereby reducing vascular adhesion molecules and inflammatory signalingmechanistic links consistent with endothelial and renal benefits of GLP-1R agonists beyond glycemic control [22, 23]

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The reason for this mild profile is partly biological

43,44 Xenogenic hPSC applications in nonhuman primates and allogeneic transplantation of cynomolgus monkey iPSC-CMs have yielded comparable results under strong immunosuppression