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Further, while adoptive transfer experiments showed that D5 signaling drives T reg suppressive functions, in nave CD4 + T-cells, D5 signaling increased proliferation and increased the differentiation of the T h 17 inflammatory phenotype in the early stages of EAE (Osorio-Barrios et al., 2018)

One difference between their model and the one reported here is that deletion of Gclc is induced in hepatocytes of adult mice (which are slowly proliferating), compared to theirs, where deletion of Gclc occurred in hepatocytes of growing animals (which are rapidly proliferating)

W., Kios, M