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As such, it is estimated that 60 million Americans consume APAP on a weekly basis ( Acetaminophen hepatotoxicity is characterized by acute liver failure, centrilobular hepatic necrosis, renal tubular necrosis and hypoglycemic coma (Lancaster et al., 2015), an outcome that can be more frequent with the use of APAP at doses above the therapeutic range
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10.1016/j.tips.2018.10.001 213 ShahM
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