In animal-model work, NNMT inhibition with 5-Amino-1MQ has been associated with changes in adipose-tissue mass, in NAD+ pool sizes (because NNMT consumes nicotinamide that would otherwise feed the NAD+ salvage pathway), and in methyl-donor dynamics (because NNMT consumes S-adenosylmethionine)
To understand the phenotypic implications of the observed sequence evolution, we characterised changes in RF, cell entry and infectious particle production over the course of the two LTXs
10.1016/j.ejphar.2017.10.044 55 LindroosP
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