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Controls received vehicle only, BSO-only group received 125 mg/kg twice daily on days 1, 2 and 3 via intraperitoneal injection, L-PAM-only group received 10 mg/kg dose on days 2 and 3 given intravenously into the lateral tail vein, and the L-PAM+BSO group received both drugs as per above

Histone acetylation and depression The first evidence of histone acetylations role in depression came from studies showing that HDAC inhibitors (HDACi), used alone or with antidepressants, enhanced antidepressant responses in animal models 139,140,141