This toolkit facilitated the categorisation of clinical recommendations according to their evidence strength, ensuring that all therapeutic applications discussed in this review are grounded in a clear, evidence-based rationale
Ferroptosis, a novel form of cell death associated with iron imbalance, reactive oxygen species (ROS) accumulation, and mitochondrial membrane damage, is closely linked to the progression of OA
The conflicting findings regarding M1 and M2 macrophage polarization suggest that the effects of NAC may be context-dependent, influenced by factors such as concentration, cell type, and specific microenvironmental conditions
Functionally equivalent to the lyophilized vial for in vitro use
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