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Institutional review board statement The study was conducted following the Good Clinical Practice standards and the Helsinki Declaration, and approved by the Ethical Committee of the University of Cagliari (protocol PG/2018/16313)

Jacques et al, 1996), and an interaction between vitamin B 6 deficiency and heterozygous CBS defects might be expected

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To investigate the mechanisms by which ibuprofen affect mouse liver, a quantitative LC-MS/MS technique using tandem mass tag (TMT) labeling was carried out to measure whole liver proteome changes after short-term (7 days) treatment of ibuprofen (100 mg/kg/day)