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Critically, GIP receptor activation in adipose (fat) tissue appears to enhance fat mobilization and energy expenditure beyond what GLP-1 can do alone which helps explain tirzepatides superior weight loss outcomes in clinical trials

Thanks to a mechanism that stimulates insulin and reduces glucagon secretions in a glucose-dependent manner, semaglutide has been shown to reduce fasting and postprandial blood glucose levels

Avoid large, heavy meals that sit in the stomach too long

Some patients may discuss switching from semaglutide to tirzepatide if progress has slowed, side effects are difficult to manage, appetite control is not adequate or the provider believes another option may better fit the patients metabolic needs

This results in harder, drier stools that are difficult to pass