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Diet-induced obese animals exhibit indices of altered central monoaminergic neurotransmission, including reduced hypothalamic 1 adrenoceptor binding, enhanced electrophysiological responsiveness to norepinephrine application, decreased basal hypothalamic serotonin and dopamine levels, and reduced mesolimbic dopamine activity

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The absence of an identifiable cause does not mean the lesion is suspicious

van Bloemendaal L, IJzerman RG, Ten Kulve JS, Barkhof F, Konrad RJ, Drent ML, et al

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