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Phelan-McDermid syndrome: a review of the literature and practice parameters for medical assessment and monitoring

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[23] [24] Prochlorperazine (Compazine) and promethazine (Phenergan) are alternative options but may cause significant sedation and anticholinergic effects

Moreover, studies have demonstrated that the efficacy of different combinations is also influenced by molar ratio, and the externalization of synergy strongly depends on the inflow of free radicals (147)