Incorporation of non-invasive parameters to assess steatosis, inflammation and fibrosis in addition to considering adaptive trial designs are potential approaches.
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The tirzepatide weight loss timeline shows progressive results over the first 40 to 72 weeks, with the most rapid loss often occurring in the middle months of treatment as the dose reaches therapeutic levels
Two-photon absorption and the design of two-photon dyes
Given the magnitude of the unmet need in obesity and the strength of the data seen so far, priority review is a realistic possibility