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Sterile water has no preservative and is strictly for single-use applications, as it can become contaminated after being opened

Metformin use and vitamin B 12 deficiency in people with type 2 diabetes

Histamine issues or mast cell activation syndrome

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Unlike approved agents such as semaglutide (Wegovy) or tirzepatide (Zepbound), retatrutide has not yet received marketing authorisation from the Medicines and Healthcare products Regulatory Agency (MHRA) or the European Medicines Agency (EMA) for use in the United Kingdom