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The Role of Toll-like Receptor 2 (TLR2) in the development and progression of Hashimotos Disease (HD): a case study on female patients in Poland

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Notably absent from areas of active demyelination are significant numbers of lymphocytes, and any lymphocytic infiltrates that were present were distant from regions of myelin and axonal injury (Machado-Santos et al., 2018)

Think of these receptors as the volume knobs for arousal

The specific subclass of the IgG response also correlates with severity, with the potent immune-activating IgG1 and IgG3 (and particularly the combination of the two) being the most common in severe cases [181,182,183]