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doi:10.1152/ajpgi.90321.2008 Okada R, Maeda K, Nishiyama T, Aoyama S, Tozuka Z, Hiratsuka A, Ikeda T, Kusuhara H, Sugiyama Y (2011) Involvement of different human glutathione transferase isoforms in the glutathione conjugation of reactive metabolites of troglitazone

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Consequently, the magnitude of weight loss benefit in multi-agonist therapies has shown dependence on glucagon activity: a balanced ratio of GLP-1 and glucagon receptors co-agonism achieves maximal weight loss without hyperglycaemia in contrast to dual-agonists with lower glucagon receptor potency or enhanced glucagon receptor activity [89]

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