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Lower pools of reduced glutathione have been associated with the severity of the autoimmune response, cell apoptosis (death), and autoantibody production

When CYP1A2 (Phase I) oxidizes an aromatic amine to its N-hydroxy derivative, and then O-acetyltransferase activity (catalyzed by the same NAT enzymes) transfers an acetyl group to the oxygen, it creates a highly reactive N-acetoxyarylamine that binds DNA