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Consistent with the in vivo findings, Acsl4 knockout in mouse renal tubular epithelial cell lines (MTECs) resulted in decreased lipid peroxidation and mitigation of mitochondrial dysfunction, thus reducing calcium oxalate (CaOX)-induced ferroptosis

10.1016/j.lfs.2021.119523 91 ShangJ.LiuF.ZhangB.DongK.LuM.JiangR.et al (2021)

Zhang Z, Lei M, Liu R, Gao Y, Xu M, Zhang M

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Klisyri can now be used to treat lesions up to 100 cm 2 caused by the pre-cancerous dermatological condition, after safety and tolerability profiles were consistent with original pivotal trial results