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Furthermore, these hormones increase bronchiole dilation, resulting in enhanced oxygen uptake ( Furthermore, the adrenal glands produce dehydroepiandrosterone (DHEA) and its sulfate (DHEA-S), which are precursors of sex hormones that influence sexual development and reproductive function

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The same study also showed that gemigliptin increased the inhibition of cell proliferation and migration induced by metformin by involving of ERK,MMP-2-9, p53, p21, VCAM-1, and (Kim et al., 2018a)