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Although liver cirrhosis of viral etiology remains the leading cause of liver-related mortality, followed by alcohol-related chronic liver disease, there is an exponential rise in steatosis- and metabolic-related chronic liver disease due to the epidemic increase in obesity and diabetes mellitus

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His/His SULT1A1 + null GSTM1/GSTT1: Low SULT1A1 sulfation reduces the parallel catechol estrogen inactivation route increasing the proportion of catechol estrogens that remain available for quinone-forming oxidation