This status quo reflects the complexity of the human brain and spinal cord and lack of fundamental knowledge of multiple pathophysiological mechanisms underlying neurological disorders
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This is specifically manifested by increased mitochondrial DNA content, upregulation of related gene expression, improvement of the oxidative metabolism, and elevation of the expression levels of key proteins involved in oxidative phosphorylation [26]
Nene S, Gelabert HA, Moore W, Quinones-Baldrich W, Santibanez-Gallerani A, Ignarro L