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Naevomelanocytic naevi may thus be manifestations of a developmental malformation or of hyperplasia of melanocytes [34, 42]

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The ASA emphasized an individualized, risk-based approach, particularly for patients in the initial dose-escalation phase (typically 48 wk after initiating therapy) or those experiencing severe gastrointestinal symptoms.The BJA, in contrast, advocates a more flexible and individualized management strategy

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