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CETSA is based on the principle that target proteins often become stabilized upon binding with small molecules, leading to a slower degradation rate under increasing temperatures [29]

Discussion The biotransformation of drugs usually leads to an increase of hydrophicility of a parent compound to support its excretion from the organism

A mixture of 200 L substrate application solution, 20 L of enzyme working fluid, and 20 L of enzyme solution was incubated at 37C for 20 min, and measured using spectrophotometry at 450 nm

People with diabetes should monitor blood sugar levels when taking glucosamine, as some studies suggest it may affect glucose metabolism