RNS include free radicals like nitric oxide ( NO) and nitrogen dioxide ( NO 2 - ), as well as nonradicals such as peroxynitrite (ONOO - ), nitrous oxide (HNO 2 ) and alkyl peroxynitrates (RONOO) [8, 10]
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[78] found that cells were highly sensitive to peroxide-induced ferroptosis by replacing selenocysteine in GPX4 with cysteine, demonstrating the importance of selenium for GPX4 to function as an antioxidant against ferroptosis
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Similar to other studies, more needs to be explored as to how NAC influences glutathione levels, factors that modify individual response to supplementation and how symptomatology interrelates