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This work is also funded by Japan Agency for Medical Research and Development (AMED-LEAP, grant# 23gm0010006h0005 (T.M.)), the Research Grant by Gutenberg Circle, Strasbourg (T.M.) and Japan Society for the Promotion of Science (Grants-in-Aid for Scientific Research KAKENHI, grant# 21H05122 and 23H02684 (S.A.))