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The textbooks describe a clear hierarchy of approaches: Steps that begin with general dental care: Prompt biopsy of any suspicious pigmented oral lesion, with histopathological examination and immunohistochemistry (S-100, HMB-45, SOX10, MART-1) to confirm the diagnosis
By way of comparison, phentermine, which is an option for short-term (less than three months) weight management therapy in conjunction with lifestyle modification, is associated with weight loss that is about 3.6 kg greater than with placebo (95% confidence interval [CI], 0.6 to 6.0 kg)
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