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Glucagon receptor activation stimulates hepatic gluconeogenesis from amino acid substrates, but it also drives lipolysis preferentially in visceral fat the metabolically dangerous fat depot surrounding internal organs

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Youve established your injection routine (same day each week, same general time, same injection site rotation)

However, semaglutide's liver effects are largely indirect, mediated through weight loss and improved metabolic parameters rather than direct hepatic lipid oxidation