semaglutide and b12 side effects with b12: complete guide to combination therapy GLP-1 Side Effects and Semaglutide:

*Last updated: January 2026 | Medically reviewed by R2 Medical Clinic*

Your physician may determine that you are not a good candidate for the skinny shot if you Have Type I diabetes or you are taking medications that affect insulin Have a personal or family history of medullary thyroid cancer Have personal or family history of endocrine tumors (also know as multiple endocrine neoplasias MEN2) Are unwilling to make lifestyle changes to support weight loss What are the potential side effects

Response time varies

Stopping a high dose abruptly can cause rebound hunger, rapid weight regain, and blood sugar instability

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