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Rarely, metformin can contribute to lactic acidosis, a serious condition more likely in settings such as severe kidney impairment, severe liver disease, heavy alcohol use, or acute illness with dehydration

The MHRA says a medicinal product includes any substance or combination of substances presented as having properties of preventing or treating disease in human beings

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Plasma concentrations measure approximately 200 ng/mL at age 20 and decline to approximately 80 ng/mL by age 60

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