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It is therefore plausible that direct interaction of cholesterol molecules with specific binding pockets in the GLP-1R might at least be partially responsible for cholesterol modulation of GLP-1R function

For people with type 2 diabetes, stopping GLP-1 therapy without an alternative treatment plan can lead to deteriorating glycaemic control, which increases the risk of diabetes-related complications over time

They are also known to enhance immune function and provide antioxidant benefits for the cell

Beyond kidney outcomes, semaglutide was associated with lower risk for major CV events and all-cause mortality compared with placebo (Graphic)

While the liver and kidneys handle most detoxification, the skin provides a secondary route, and increased sweating can reduce overall toxin burden