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65: 2397-2410 (2019) Abel J, Haarmann-Stemmann T

Physiol Behav (2008) 94(5):6704

83 However, within the tumor niche, cancer cells, MDSCs, TAMs, suppressive DCs, and cancer-associated fibroblasts, among other cell types, exhibit upregulated expression of indoleamine 2,3-dioxygenase (IDO), which metabolizes tryptophan into suppressive kynurenine to promote Tregs and suppress CD8 + T cell function

At least two of the five peptides were detected in most sawfly species, whereas none in any outgroup taxon

The study encompassed five different ICI-based treatment modalities, including fecal microbial transplantation (FMT)