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9 kg), reduces depression scores and improves QoL dimensions such as mood and self-image, with changes correlating with the magnitude of weight loss ( 5 Safety, clinical tolerability, and periconception management strategies From the perspective of actionable clinical management, this section categorizes three core challenges associated with the use of GLP-1RAs in women of reproductive age with PCOS: (i) discontinuity in adherence driven by gastrointestinal adverse effects

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Fructose and vitamin C intake do not influence risk for developing hypertension