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The large jaw that is typical of acromegaly, as you can see below, is due to excessive bone growth

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doi: 10.1210/endo.136.8.7628397 100 VahlTPPatyBWFullerBDPrigeonRLDAlessioDA

In this regard, proteolysis-targeting chimeras (PROTACs) containing a ligand for target protein and a recognition motif for E3 ubiquitin ligase recruitment are candidates for ER degradation and inhibition of cancerous cell growth

The decision was not related to data from any clinical program and there have been no observed or reported safety concerns, Equillium stated