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The participants were recruited through Rotterdam criteria of 2004 and randomly distributed into three groups: acupuncture + placebo( n = 114), metformin + sham acupuncture( n = 114) and sham acupuncture + placebo( n = 114)

E 2( t ) itself is a piecewise linear function found by applying the spline function in Matlab to the data in Panel A of Figure 2 for estradiol as a function of day of the cycle for the average woman

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