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Having low levels of vitamin B12 in the body is associated with a high risk of developing depression

It directly addresses the IRS requirement that the expense is for mitigating a disease

In phase 1b and 2 studies, pharmacokinetic assessments showed a mean elimination half-life of approximately 6 days, supporting once-weekly dosing and stable steady-state exposure after 46 weeks

Notably, SGLT-2is are medications of small molecular weight, with lower LogP oct than the permeation prediction index of BBB (listed in Table 2)