In CIPN in vivo models induced by cisplatin, postmitotic sensory neurons in the dorsal root ganglion (DRG) are particularly sensitive to cisplatin injury, and axonal damage induced by cisplatin involves multiple events, including ROS generation, suggesting that antioxidants may help reduce the neurotoxicity of cisplatin [124, 125]
GLP-1RAs improve glycemic regulation by signaling through the GLP-1R to stimulate insulin biosynthesis and release, suppress glucagon release, delay gastric emptying, and improve glucose metabolism [59]
A 0.5 mL draw on a TB syringe is equivalent to 50 units on a U-100 insulin syringe
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not FDA-approved and used only in a research context