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We understand that off-label prescribing can be beneficial in some circumstances, but we cannot support it when it is directly contributing to ongoing shortages for people living with type 2 diabetes and the impact this has on managing it well, said Douglas Twenefour, the head of care at Diabetes UK

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Note that cuprizone application [232] was an extremely high regimen and much higher than those commonly applied to mimic multiple sclerosis in rats [243,244])

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