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American Journal of Surgery

For researchers evaluating these compounds, Dihexa offers more direct cognitive enhancement data and the practical advantage of oral bioavailability, but at the cost of greater mechanistic safety concerns and a compromised publication record

Fats can take longer to digest, which can make side effects worse, or make you feel too full for too long

The evidence base includes STEP (semaglutide for weight management, NEJM 2021), SURMOUNT (tirzepatide for weight management, NEJM 2022), and SURMOUNT-OSA (tirzepatide for obstructive sleep apnea, NEJM 2024)

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