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Blum and others began prescribing these lower doses to healthy patients in 2024

Reduced Appetite: While beneficial for weight loss, some patients may find it difficult to eat enough nutrients

In future, once data are available on a larger number of patients switching treatments, the use of administrative claims data in similar analyses would help to increase confidence that the patients represented are those who have collected and adhered to treatment following switching

This prolonged retention can increase gastric pressure and potentially allow stomach acid to reflux back into the oesophagus, causing the burning sensation characteristic of heartburn or gastro-oesophageal reflux disease (GORD)

The patient who needs rapid, clinically significant weight loss for diabetes management is not the same patient as the one who wants to reduce visceral fat while preserving the lean mass they have built over years of training