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Combination protocols give both an immediate GH pulse (from Ipamorelin) and a slightly extended pulse (from mod CJC), though still shorter than the DAC versions multi-day effect

They confirmed the long-lasting antidepressant effect of a single injection of ketamine and observed changes in synaptic plasticity resulting from persistent changes in dendritic spines and synapse-associated proteins

J Neurosci 42(45):85428555 Wang JH, Thampatty BP (2008) Mechanobiology of adult and stem cells

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While BDNF supports plasticity via TrkB, proBDNF can activate p75 receptors and trigger apoptosis [67, 349]