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Based on these data, an ongoing phase 1/2a, multicenter, open-label, ascending dose, first in-human clinical trial is planned to evaluate the safety of intracisternal PR001A (AAV9-GBA1) administration in patients with moderate to severe PD with at least one GBA pathogenic variant (NCT04127578, Table 2)

Taper fluid intake as bedtime approaches to avoid disrupting sleep with frequent trips to the bathroom

Chaudhry et al

Many people achieve satisfactory results at 10mg or 12.5mg, and the clinical trials showed meaningful weight loss at every dose level above 5mg

1 This medication works to stimulate insulin secretion in a glucose-dependent manner, therefore decreasing the risk of hypoglycemia