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By inhibiting DPP-4, these drugs prolong incretin activity, leading to: Glucose-dependent insulin secretion from beta cells Suppression of glucagon from alpha cells Improved postprandial blood glucose control This mechanism does not stimulate insulin release in absence of glucose, making hypoglycemia rare

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E., Duprey, J., Cruz, J

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Folate, B6, and niacin also decline measurably when caloric intake drops below 1,500 calories daily

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