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Retevmo is specifically indicated for advanced or metastatic medullary thyroid cancer with a RET mutation, advanced or metastatic thyroid cancer with a RET gene fusion untreatable with radioactive iodine therapy, and locally advanced or metastatic solid tumors with a RET gene fusion that have progressed after prior systemic treatment or have no treatment options, according to the publication

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Ferroptotic cell death can exacerbate inflammation through DAMP release, like activating NF-B via its receptor for advanced glycation end-products (RAGE) 41

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