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During the randomized treatment period, patients received a standard lifestyle instruction every 12 weeks on reduced-calorie diet (approximately 500 kcal/day deficit) and increased physical activity (recommended minimum of 150 min/week) that began with the first dose of ZEPBOUND or placebo and continued throughout the 72-week treatment period

Increased expression of -catenin improves BMD by inducing the BMSC to differentiate into osteoblasts that maintain the bone microarchitecture, enhance its density, and restore the normal balance that the estrogen deficiency disrupted (Chen & Long 2013)

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Calcium, ischemia and excitotoxicity

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