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Biomaterials 221 , 119416 (2019)

Due to its poor lipophilicity, metformin does not cross cell membranes by simple passive diffusion and its bio-distribution relies on tissue-specific transporters, including plasma membrane monoamine transporter (PMAT) in the intestine, organic cation transporter 1 (OCT1) in the liver, and both organic cation transporter 2 (OCT2) and multidrug and toxin extruder (MATE)1/2 in the kidneys (, )

BPC 157-rats (10, 11) presented the surface epithelium largely preserved with minor subepithelial foci of mononuclear inflammatory cells (10