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Therefore, creatine supplementation is being investigated as a strategy to attenuate aging-related conditions (such as sarcopenia) and muscular dystrophies, with studies reporting potential benefits for muscle strength 9,10 , but with limited effects in metabolic myopathies 11

maintenance phase is the heavy draw 26 weeks 13 vials Standard Phase 2 duration 32 weeks 16 vials Phase 2 T2D study duration 68 weeks 30 vials REDEFINE 1 / REDEFINE 2 endpoint duration Peptide Vials (10 mg vial, 2.4 mg/week target) Each 10 mg vial covers about 4 weekly doses at 2.4 mg/week

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doi: 10.1136/gutjnl-2011-300269 44 LiuLHeSJiaLYaoHZhouDGuoXet al