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Because GH stimulates the liver to produce IGF-1, levels must be kept within a safe, physiological range to avoid potential risks related to cellular proliferation

Understanding these factors is useful for patients who may be considering participation in a trial or who wish to discuss emerging therapies with their healthcare provider

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Studies using rat pinealocytes demonstrated that Epithalon upregulates both arylalkylamine N-acetyltransferase (AANAT) and phosphorylated CREB (pCREB), the rate-limiting enzymes in melatonin synthesis