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This isoform performs the same enzymatic reaction as ACSS2 in the mitochondria, primarily generating acetyl-CoA through fatty acid oxidation, which is further oxidized to CO [60]

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The rapidly evolving landscape for CKD-protective therapies in type 2 diabetes currently includes sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1 RA), both of which demonstrate cardiorenal outcome benefits

Beyond rest, sleep regulates cortisol, the stress hormone

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