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We furthermore thank Luise Krauth-Siegel for helpful discussions and Tobias Dick and Bruce Morgan for reading an initial version of the manuscript and suggestions

However, the natural form of GLP-1 is quickly broken down in the body by an enzyme called dipeptidyl peptidase-4 (DPP-4)

The most valuable metabolic franchises won't come from out-competing Lilly and Novo in obesity - they'll come from redeploying GLP-1 science where indication choice creates reimbursement advantages.