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Previously, it was reported that this pathway is highly strongly associated with somatization disorder, a psychiatric disease accompanied by psychosomatic symptoms but not necessarily by fatigue ( Terms Overrepresented in the Wnt Multiomics Subnetwork Our enrichment analyses revealed that the CFAS-D network was highly significantly associated with two major interrelated functions/pathways/domains, namely, the canonical Wnt/-catenin pathway, T-cell factor (TCF)-dependent signaling in response to Wnt, degradation of -catenin by the destruction complex, the -catenin complex and DIX domain, and adherens junctions, cadherin prodomain, and cellcell junctions

B., & Shyu, W

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In contrast, GPX4 prevents ferroptosis by using GSH to convert lipid hydroperoxides into non-toxic lipid alcohols, reducing oxidative stress and protecting against ferroptosis [19]

It was found that in CT and TT populations, the activity of MTHFR was only 65% and 30% of that in CC populations